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Work to install two bridges which will form the new junction 10a will shut the M20 for two full weekends.
Highways England is to close the motorway in Ashford from Friday, January 11 at 10pm to Monday, January 14 at 6am and January 25 to 28 over the same time period.
It is not yet known which areas the closures will cover, but the coastbound route between Junction 9 for Ashford and 11 for Hythe was closed when the Kingsford Street footbridge was installed in November.
The London-bound stretch between Junctions 11 and 10 was also shut off to motorists in the same period.
Bosses say the steelwork for the east and west gyratory bridges will be installed during the closures.
Both closures are weather dependent, with contingency weekends planned for January 18-21 and February 1-4.
Junction 10a - which is costing £104m - is expected to open to traffic next autumn and is being built just 700 metres away from the current junction 10.
The M20 has already been reduced to two lanes in both directions around the site of the new junction.
A 50mph limit is also in place - and will stay in force until 2020.
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