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Police were called to the scene of a serious incident in Canterbury.
Several ambulances were also sent to the city's bus station and cordoned off an area around a bus.
Footage from the scene
Stagecoach tweeted that the 3.50pm service from Canterbury to Folkestone had to be cancelled "due to an incident on the bus".
An eyewitness told KentOnline several people were "trapped" on the top deck of the vehicle.
Police say they were called at 3.54pm to "a medical incident" in St George’s Lane, Canterbury.
A Stagecoach spokesman said: "We can confirm that police and paramedics attended a bus at Canterbury bus station this afternoon.
"A passenger on board the bus was taken ill and required emergency medical attention.
"No other passengers were involved and the emergency services have now left the scene."