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Emergency roadworks mean a major route between Kent and Essex will be closed for part of the weekend.
The Dartford Crossing will be partially closed overnight from 10pm on Sunday.
The tunnels will re-open at 5am on Monday, May 14.
Motorists will face closures on the M25 anti-clockwise from junction 1A to junction 31.
Highways England has also announced further closures in the coming weeks, as routine maintenance is set to continue at the crossing.
There will be a number of closures overnight between 8.30pm and 5.30am.
Fully signed diversions will be in place during the northbound east tunnel closures for oversized vehicles.
Work will be carried out on the northbound east tunnel between Monday, May 14 and Friday, May 18.
Maintenance will also take place overnight on the northbound west tunnel on Saturday, May 19.
Work will finish on the northbound east tunnel overnight on Sunday, May 20.