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Traffic is queueing near the Dartford Crossing due to a collision involving a car and a lorry.
Motorists are facing delays due to the incident, with normal traffic conditions expected to return at about 6pm.
It happened at Junction 2 of the A2, for the Darenth Interchange, and has caused one lane of the M25 anti-clockwise route to be closed.
Images from nearby traffic cameras show cars queueing on the slip road.
Police and the ambulance serivce have been contacted for more information.