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The A2 near Dartford was closed following a serious crash - and didn't reopen for more than 12 hours.
Two lorries collided on the coast-bound carriageway between the A2018 Old Bexley Lane (Dartford Heath) and the M25 J2 (Darenth Interchange).
Officers were called at 4.20am and the London-bound carriageway was also closed to allow the air ambulance to land. It has since reopened.
A diversion was in place via the A2018, B2174 and A225 through Dartford to re-join at J1B of the M25.
Police described it as a "serious injury accident" and Highways England warned the closure was likely to remain in place into the evening while "complex collision investigation work" took place.
One witness who drove past the scene on his way to work said he "never seen anything like it".
Jamie Ruck added: "When I drove past the air ambulance was there, several fire crew members as well as police including forensics and multiple ambulance crews.
"They were followed by the traffic officers that was turning traffic around to clear the dual carriageway and allow the police and other emergency services to carry out their jobs.
"It just puts it into perspective how dangerous driving can actually be."
Another witness described how a Royal Mail lorry had gone into the back of another lorry and the cab had "disappeared into the trailer of the front lorry".
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