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Drivers faced traffic chaos after the M25 was closed due to a serious collision involving three vehicles.
Emergency services were called to the scene of the crash, believed to involve a lorry, between junction 2 and junction 3 heading clockwise near Darenth.
Highways England tweeted to confirm the road had reopened at around 1am.
Motorists were advised to avoid the area and use alternative routes.
At the time of the crash, spokesman Natalie Hardy said: "The M25 is closed between junction 2 and 3 clockwise following a serious collision involving three vehicles.
"Kent Police was notified of the incident at around 8pm and officers are currently at the scene."