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Lorry tailback at the scene of the crash on the A2 at Guston near Dover
That section of the A2 was closed in both directions for more than six hours while crash investigators worked at the scene.
The crash involved a white lorry with green markings, a silver Skoda and a silver Alfa.
Kent Fire and Rescue Service crews worked to rescue some of the vehicle occupants and two air ambulances landed at the scene.
Police are keen to speak to the driver of a vehicle travelling in front of the lorry before the crash.
Insp Martin Stevens, from the Kent Police Serious Collision Investigation Unit, said: "Thank you to everyone who has contacted us with information about this incident. I'd urge anyone else who may have information that could help with our enquiries to contact us.
"We are particularly keen to speak with the driver of an unknown car who was travelling in front of the lorry before the collision as they may have information which could help with our investigation."