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Two drivers from a four-car crash in Folkestone Road (B2011) are in hospital and are said to be in a critical condition.
The incident happened just before 11.30 last night, involving a head-on collision with a silver Audi estate and a green Range Rover.
Once they had collided this led to the crash of two other vehicles.
Three people have been arrested in connection with this incident; a 45-year-old man, a 50-year-old man and a 24-year-old man. They all remain in custody.
One victim had to be cut free after becoming trapped in his car, and was treated at the scene by paramedics.
The driver of the Range Rover, a 45-year-old man, remains in hospital with injuries described as serious.
The driver of the Audi, 32, is believed to be from the Dover area and has been transferred to Kings College in London where he remains in a "critical condition."
A statement released by Kent Fire and Rescue said: "One man was trapped and firefighters stabilised the vehicle before removing the roof using hydraulic rescue equipment.
"He was placed on a spinal board and handed into the the care of the ambulance service."
The road was closed until 7am this morning.
Officers from the Serious Collision Investigation Unit carried out an investigation, the vehicles were recovered and the debris was cleared from the road.
Officers are appealing to anyone who witnessed the collision or saw the vehicles travelling before the collision to contact police as they may be able to help officers with their enquiries.
If you have information please contact DC David Holmes at the Serious Collision Investigation Unit on 01622 798538.