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Night-time closures on the M2 will be in place for a month with the works demanding a mega 70-mile diversion route.
The resurfacing of the coastbound stretch between junction 5 for Sittingbourne and junction 6 for Faversham starts on Tuesday.
Closures will be in place on Monday to Thursday nights until September 30 from 8pm to 6am.
But the road will be open as usual on Friday, Saturday and Sunday nights during this period.
Highways England have told drivers the main diversion route will take drivers around the A249, M20 and A2 via Ashford, Dover and Folkestone and back to Brenley Corner to rejoin the M2 at junction 7.
A statement from the roads agency said: "Please be aware that these works are subject to change due to weather conditions or unforeseen circumstances.
"The overnight closures will be clearly marked on yellow signs at the junction/alongside the road and emergency services vehicles will have escorted access through the works where required."
Although the works will not coincide, drivers will need to plan ahead due to further weekend closures on the A2 between Canterbury and Faversham also starting next week.
The stretch will be closed for up to six straight weekends from September 3 between 8pm and 6am from Fridays to Mondays.
A further four weekend closures could be enforced along the six-mile stretch - between Brenley Corner and the Wincheap Interchange - in the weeks up to November 22.
A 40-mile diversion is in place for these resurfacing works.
It will be along the A299 Thanet Way to the Sevenscore roundabout near Cliffsend and down the A256 towards Dover, and vice versa
The works on both the A2 and the M2 are much-needed with the carriageways littered with potholes and dips and heavy use from lorries and regular traffic.
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