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A motorist is in hospital with life-threatening injuries and one of the county's major roads is closed after a serious accident.
The crash happened at around 4am at junction 3 of the M25 going onto the A20 Swanley interchange.
The incident has caused rush hour chaos as the M20 London-bound is closed at Swanley.
Police say the road is expected to remain shut "for some hours".
Motorists are advised to avoid the area if at all possible.