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A stretch of the M25 was closed for 11 hours after a serious crash near Orpington.
Emergency services were called at around 4pm this afternoon - with police, fire crews and ambulances summoned.
It has led to the anti-clockwise section of the motorway between Junction 3, for the Swanley Interchange and Junction 4 for Cobham being closed.
Kent Police said this evening: "The road is likely to remain closed for a lengthy period of time and drivers are urged to plan alternative routes."
The road reopened at around 3.30am.