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Two men and a woman were killed in a head-on crash involving a car and a pick-up truck on the A20 at Wrotham.
According to a police spokesman, a Mercedes C200 was travelling up Wrotham Hill when it collided with a Toyota Hi-Lux travelling in the opposite direction just after 4pm Sunday.
A 63-year-old man driving the car, his 78-year-old female passenger and a 48-year-old male passenger in the Toyota all died.
The male driver and two other women travelling in the pick-up truck were all taken to hospital in Maidstone with serious injuries.
The stretch of road where the accident happened is where the A20 climbs up a hill towards West Kingsdown, after the road crosses the M20 motorway.
One resident of Wrotham Hill, who asked not to be named, said: "It happened on the stretch of road parallel with Old Coach Road, which overlooks the A20.
"It is a busy part of the A20 and well used by locals and traffic from out of the area. It can get really busy if there is a hold up or problem on the M20, or M26, which are nearby."
The road was closed until around 7am Monday after the crash.
Anyone with information is urged to contact Kent Police's Serious Collision Investigation Unit on 01622 798538.