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Drivers are being warned of disruption as urgent resurfacing work is carried out on the A299 Thanet Way.
Kent County Council says it is being done to ensure the "key strategic route" remains in a suitable condition as part of the UK's Brexit preparations.
Work is due to begin overnight on Monday and Tuesday between Brenley Corner and Clapham Hill Interchange in Whitstable.
The diversion route will be via the A2 Boughton Bypass, A2050 London Road, A290 Bean Hill/Honey Hill/Pean Hill and Clapham Hill.
A second phase of work will take place overnight on Wednesday, Thursday, and Friday from Clapham Hill to the Eddington Interchange in Herne Bay.
Chestfield Tunnel maintenance will also be carried out on the London-bound carriageway.
The diversion route will be via the A2990 Thanet Way from Clapham Hill Interchange, Whitstable, to the Eddington Interchange and vice versa.
A KCC spokesman said: "About two kilometres of lane one of the coastbound section, mainly within the Canterbury district, is being resurfaced overnight.
"However, to ensure the safety of workmen,a longer stretch of the road needs to be closed from 8pm to 6am."
The government earlier said it would spend a further £20 million to help efforts to mitigate the threat of disruption and delays on Kent roads after Brexit.
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