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A fire at a signalling box at Sittingbourne is causing problems on Medway's trains.
Bus replacement services are operating between Gillingham and Faversham and Sittingbourne and Sheerness.
Limited rail services are running between London Victoria and Gillingham and Faversham and Dover.
Network Rail is carrying out emergency engineering works and the disruption is expected to last for several hours.
Commuters should check National Rail Enquiries for more information.