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The American government has named Chatham's Sally Jones as a "specially designated global terrorist" on its Federal Register.
The move means Jones - a mum-of-two and recently a grandmother - is now the world's most wanted female terrorist and could be targeted in Syria by coalition airstrikes.
It was sanctioned by US secretary John Kerry, before the 46-year-old was added to a separate United Nations sanctions list, freezing her assets.
Jones joined Islamic State in 2013, marrying Isis computer hacker Junaid Hussain and moving to Syria herself.
Hussain - the most prominent British member of Islamic State after the man known as "Jihadi John" - was then killed in a US airstrike in August.
A former guitarist with an all-girl rock band, she had previously moved from Chatham to Borough Green, where it is thought she was receiving grocery parcels from a church-organised food bank just weeks before moving to Syria.
She has since posted pro-Isis statements from a series of Twitter accounts and encouraged Brits to carry out terror attacks.
The notice from the US Secretary of State on the Federal Register states: "I hereby determine that the individual known as Sally-Anne Frances Jones, also known as Sally Anne Jones, also known as Sally Jones, also known as Umm Hussain al-Britani, also known as Sakinah Hussain poses a significant risk of committing acts of terrorism that threaten the security of U.S.nationals or the national security, foreign policy, or economy of the United States."