Health Secretary Matt Hancock has warned Britain is at a “tipping point” as he refused to rule out a second national coronavirus lockdown if the public fails to follow social distancing rules.

With cases rising across the country, Mr Hancock said there was a danger the numbers could “shoot through the roof” unless effective action was taken to halt the spread of the virus.

Mayor of London Sadiq Khan pressed ministers to extend the controls to the capital, which he believes may be just “two or three days” behind the hotspots of the north-west and north-east of England.

His spokesperson said: “The situation is clearly worsening. Sadiq will meet council leaders tomorrow and any London-specific measures will be recommended to ministers following that.

“The mayor wants fast action as we cannot risk a delay, as happened in March. It is better for both health and business to move too early than too late.”

Mr Hancock’s warning came as the Government announced anyone in England who refuses an order to self-isolate could face a fine of up to £10,000.

The Health Secretary said hospital admissions for the disease were doubling “every eight days” and would be followed by an increase in the number of deaths.

“This country faces a tipping point,” he told BBC1’s The Andrew Marr Show.

“If everybody follows the rules – and we will be increasingly stringent on the people who are not following the rules – then we can avoid further national lockdowns.

“But we of course have to be prepared to take action if that’s what’s necessary.”

Another 3,899 lab-confirmed cases of coronavirus in the UK were announced on Sunday, bringing the total to 394,257, while a further 18 people had died within 28 days of testing positive, bringing the UK total to 41,777.

During a round of broadcast interviews, Mr Hancock said the Government had taken the decision to impose a legal duty on people to self-isolate if instructed as the data showed some were failing to do so.

At the same time ministers have said people on benefits in England will be eligible for a one off support payment of £500 if they face a loss of earnings as a result of being required to self-isolate.

Mr Hancock told Sky News’ Sophy Ridge On Sunday programme: “We will support people who do the right thing and we will come down hard on people who do the wrong thing.”

Boris Johnson has been desperate to avoid another nationwide lockdown amid concerns about the economic damage it will inflict just as activity was beginning to pick up again.

However, as of Tuesday, around 13.5 million people across the UK will be facing some form of local restrictions as the authorities grapple with the disease.

Mr Hancock said he was “very worried” about the latest data which suggested Britain could be on the same path as Spain and France – where deaths and hospitalisations are increasing – without effective action.

“I am very worried about this second wave. We have seen in other countries around Europe how it can absolutely shoot through the roof,” he said.

“When the case rate shoots up, the next thing that happens is the numbers going into hospital shoot up.

“Sadly, we have seen that rise, it is doubling every eight days or so – people going into hospital – then, with a lag, you see the number of people dying sadly rise.”

Professor Chris Whitty, the chief medical officer for England, and Sir Patrick Vallance, the Government’s chief scientific adviser, are expected to set out the latest scientific evidence in a televised briefing on Monday ahead of a possible press conference by Mr Johnson the following day.

Among the measures being considered by ministers is a temporary two-week “circuit break” with tighter restrictions across England in an attempt to break the chain of transmission.

However, the Government is facing resistance from some senior Conservative MPs concerned that ministers are taking increasingly stringent powers with little or no parliamentary scrutiny.

Sir Graham Brady, chairman of the powerful Tory backbench 1922 Committee, said he will table an amendment which would require the Government to put any new measures to a vote of MPs.

He told The Sunday Telegraph he would take the opportunity to seek to amend the legislation when the Government comes to renew the emergency powers in the Coronavirus Act 2020.

“In March, Parliament gave the Government sweeping emergency powers at a time when Parliament was about to go into recess and there was realistic concern that NHS care capacity might be overwhelmed by Covid-19,” he told the paper.

“We now know that the NHS coped well with the challenge of the virus and Parliament has been sitting largely since April. There is now no justification for ministers ruling by emergency powers without reference to normal democratic processes.”

Under the latest rules, from September 28 people in England will have a duty to self isolate for 14 days if they test positive for coronavirus or they are instructed to do by NHS Test and Trace because they have been in contact with someone with the disease.

Sir Keir Starmer said Labour would support the measures but warned that a second national lockdown was becoming more likely because the Test and Trace programme was in a state of “near collapse”.

“Because the Government’s now effectively lost control of testing, it doesn’t necessarily know where the virus is. So if I was the prime minister, I would apologise for the fact that testing is all over the place,” he told the Sophy Ridge on Sunday programme.

Mr Hancock, however, was not prepared to apologise, saying: “I will endlessly defend my team. They are doing amazing work day-in-day-out.”