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Officers investigating a serious crash on the M2 between Gillingham and Sittingbourne are appealing for witnesses.
Kent Police was called at 5.45pm on Sunday to a report of a collision involving a grey BMW 320D and a red Iveco Ford horse box on the coast-bound carriageway between Junction 4 and Junction 5.
Traffic was initially stopped and a full road closure put in place from Junction 4 at about 6.10pm.
The Londonbound carriageway was also closed at the same time to allow Kent Air Ambulance to land.
A female passenger with head injuries was flown to a hospital in London, where she remains in a stable condition.
A second person was taken by land ambulance to a hospital in Ashford.
The motorway was fully reopened by 7.45pm.
If anyone witnessed the collision or was on the motorway at that time that may have information, call 101 quoting CAD 03-1277.