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A woman has been flown to hospital after a crash on the A249.
The Maidstone-bound carriageway was blocked due to the crash near Junction 5 of the M2 at Stockbury roundabout, with delays stretching back to Sittingbourne.
An air ambulance landed by the Oad Street turning and fire and ambulance crews are also in attendance.
The crash happened at 12.35pm when a blue Ford Fiesta left the Oad Street junction in Stockbury and was involved in a crash with a white Ford Ranger travelling on the southbound carriageway of the A249 Sittingbourne Road.
The road reopened at around 6pm.
A spokesman for the South East Coast Ambulance said: "Crews attended at 12.35pm and were joined at the scene by the air ambulance service.
"One patient was airlifted to hospital in London with potentially serious injuries."
Police were also in attendance and a road closure is in place while the incident is responded to.
A spokesman for Kent Fire and Rescue Service said: "Two fire engines were sent to the scene, and crews used hydraulic rescue equipment to remove a door on one of the vehicles and release a trapped casualty."
An appeal for witnesses has been issued following a serious collision near Sittingbourne.
Officers from the Serious Collision Investigation Unit (SCIU) are appealing for witnesses or anyone who was in the area and has dashcam footage to come forward.
Witnesses should call the SCIU appeal line on 01622 798538 or sciu.td@kent.pnn.police.uk quoting DS/RF/16/22.