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Drivers are being warned to expect delays following a crash on the A228 Maidstone Road, close to Five Oak Green.
Two vehicles collided at about 10.40am between the junctions with Alders Road and Badsell Road.
The road, not far from Paddock Wood, is partially blocked in both directions.
Kent Highways has warned motorists to approach with caution and expect delays.
One patient has been taken to Tunbridge Wells Hospital but the ambulance services does not believe they suffered any serious injuries.